https://u.ae/en/information-and-ser...outbreak/vaccines-against-covid-19-in-the-uae
DUBAI (Reuters) - The UAE health ministry on Thursday approved Russia’s Sputnik V COVID-19 vaccine for emergency use, state media reported, as infection levels hit a record and only weeks after vaccine trials began in the United Arab Emirates.
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The UAE did not release data on the findings of its Phase III trials. The Russian Direct Investment Fund (RDIF), which is marketing the shot abroad, said trials began in December. Abu Dhabi announced this month the trials had started but did not say when.
https://www.pfizer.com/news/press-r...and-biontech-puresults-study-showing-covid-19The current in-vitro studyinvestigated the full setof UK strain spike mutations. To thisaim, a pseudovirus featuring the U.K. strain spike protein was generated. The pseudovirus recapitulates SARS-CoV-2 virus binding and cell entry. Sera of participants from the previously reported
German Phase 1/2 trial inhibited pseudovirus bearing the U.K. strain SARS-CoV-2 spike in a neutralization range that is regarded as biologically equivalent to the unmutated Wuhan SARS-CoV-2 spike.
While the pseudovirus system used is a surrogate for authentic SARS-CoV-2, previous studies have shown excellent concordance between pseudotype neutralization and SARS-CoV-2 neutralization assays.i The preserved neutralization of the pseudovirus bearing the U.K. strain spike by BNT162b2- immune sera makes it likely that COVID-19 caused by the U.K. virus variant will also be prevented by immunization with BNT162b2.
Pfizer and BioNTech are encouraged by these early in vitro study findings. Further data are needed to monitor the Pfizer-BioNTech COVID-19 vaccine’s effectiveness in preventing COVID-19 caused by new virus variants. So far, for COVID-19 vaccines, it has not been established what reduction in neutralization might indicate the need for a vaccine strain change.
A eficácia real contra as variantes pode não continuar nos 90 e tal % mas é conveniente para a empresa enfatizar os estudos laboratoriais:
A limitation of this finding is that the Y501 virus does not include the full set of spike mutations found on the rapidly spreading strains in the UK or South Africa.
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